History of EONS v1.0!
EONS V1.0
June 6, 2008: Release 88
Bugs Fixes: none.
Models modifications: Glycine transporter GlyT1 recalibrated.
Code cleanup: Metabotropic receptor type 1 has its own location and icon.
Enhancements: Added 13 states model for AMPA receptor.
EONS V1.0
January 7, 2008: Release 49
Bugs Fixes: none.
Models modifications: new layout of presynaptic VDCCs.
Code cleanup: none.
Enhancements: Added glycine transporter GlyT1 on glial cell adjacent to
the synapse that controls the amount og glycine present. Added
histamine receptor H3 that controls the level of inhibition of VDCCs.
EONS V1.0
December 3, 2007: Release 40
Bugs Fixes: logo in about window not present (ImageIcon exception);
proper initialization of AMPA5 receptors.
Models modifications: NT release uses model from Yamada and
Zucker 1992; new synapse layout to reproduce the Yamada and Zucker 1992
[Ca]pre profile (No vdcc T type, more L type); presynaptic ca buffer
modified to fit Yamada and Zucker 1992 [Ca]pre profile; NMDA has 3
conductances (Ca, Na and K).
Code cleanup: Load defaults from each model panel rather than
main frame.
Enhancements: Output graphs are generated in a smart way
(points with no information are removed (precision =
range/400)); Graph-> View dataset generates only an
output for the selected graph; Graph-> View dataset.
The X axis in the table is now in ms (and formatted); calcium buffer
has now a clearing rate accessible from the user interface.
EONS V1.0
November 2, 2007
Note: Improved user interface. Ability to close results panel to free
memory space. Feedback when the system is running low in memory space.
EONS V1.0 June
1, 2007
Note: Improved user interface: addition of zoom-in/out and pause
options during simulation. Added mechanism: nicotinic acetylcholine
receptor
EONS V1.0 May 7,
2007
Note: With long simulations, the simulations recorded too many
points which resulted in very important memory usage. The user can now
select how many points will be stored at the end of the simulation,
resulting in a significantly lower amount of memory used.
EONS V1.0
February 5, 2007
Note: With long simulations, the graphs contained too many points which
induced very slow update of the display when the user was switching
graphs or scrolling up and down. A new class checks for the
significance of the points to be displayed and hence only displays the
significant ones, resulting in much faster drawing. Updated to the
latest versions of JDK (1.5.0_11), JFreechart (1.0.3) and JCommon
(1.0.8)
EONS V1.0
January 3, 2007
Note: The animation flickering problem encountered on some machines is
fixed;
Increase in simulation speed.
EONS V1.0
November 7th 2006
Note: This version contains new postsynaptic models: slow and medium
potassium channels and new Na/Ca exchanger. This version includes all
features previously available.
EONS V1.0 August 16th 2006
Note: This version was completely remodeled. It contains new models for
calcium pumps (N, L and T types), new neurotranmitter release and new
receptors kinetics. the interface is completely rewritten. This version
includes all features previously available.
EONS Beta7 version:
September 23rd 2003
Note: This version of the model includes all features previously
available. Calcium pumps and localized buffers can be eliminated. The
neurotransmitter release approximation using a fourth power rule has
been modified; a bug in the calcium channel dynamics has also been
fixed.
EONS Beta6 version:
August 15th 2002
Note: This version of the model includes all features previously
available. The synaptic cleft has now variable width. It can vary from
6 to 40 nm (in 2nm increments).
EONS Beta5 version: April
14th 2002
Note: This version of the model includes all features previously
available. The login on the applet is disabled. Labels are added for a
more user-friendly interface. The online help is updated.
EONS Beta4 version:
October 26th 2001
Note: This version of the model includes all features previously
available. An animation illustrates the evolution of calcium
concentration in the presynaptic terminal as well as the evolution of
neurotransmitter concentration in the cleft during the simulation.
EONS Beta3 version:
September 10th 2001
Note: This version of the model includes all features previously
available. The depiction of the synaptic components is "3D-like" and
dynamic.
EONS Beta2 version: June
4th 2001
Note: This version of the model includes both the pre-synaptic and
post-synaptic part. Single pulse, paired pulse and train of pulses are
available. The geometry of the synapse can be modified; the number of
calcium channels, calcium pumps, AMPA and NMDA receptors can be changed.
EONS Beta version: May
16th 2001
Note: This version of the model is runnable. It includes both the
pre-synaptic and post-synaptic part. Single pulse, paired pulse and
train of pulses are available.
EONS Alpha version: May
10th 2001
Note: This version of the model is runnable. It includes both the
pre-synaptic and post-synaptic part (with a single pulse
depolarization). Both parts are not yet connected (model pre and
post-synaptic do not run concurrently).